Nuclear Magnetic Resonance Laboratory<\/p>\n
The NMR Laboratory, established by professor Maurizio Paci, is organized as a Center for Large Instruments of the University of Tor Vergata. As such, it is available to its use by internal groups of all departments and external users, both public and private.
\nThe laboratory is equipped with two high resolution NMR spectrometers (400 MHz Bruker Avance III and 700 MHz Bruker Avance).<\/p>\n
NMR spectroscopy can be applied to:
\n– structural analysis of organic molecules
\n– structural studies of biomolecules
\n– protein-protein interaction
\n– protein-ligand interaction
\n– study of dynamics of biomolecules
\n– folding\/unfolding characterization
\n– nanobiotechnology
\n– metabolomics
\n– food analysis<\/p>\n
These subjects include scientific areas of Physics, Chemistry, Medicine and Technology, facilitating the development of multidisciplinary studies.<\/p>\n
Research lines presently actives at the NMR Lab:
\n– Molecular basis of Friedreich Ataxia disease
\n– Search for biomarkers of cardiovascular risk
\n– Development of a Serum NMR platform for HTS metabolomics studies of population. Assessment of environmental risk and profilaxis
\n– Characterization of the Mechanism of Action of anti-Schistosomiasi drugs
\n– Development of new methods for drug discovery using NMR spectroscopy
\n– Plasma Protein Binding of drug candidates using NMR
\n– Characterization of therapeutic peptides
\n– Study of the lipid profile of bone marrow in osteoporotic patients
\n– Metabolomics applied to sport
\n– Development of new compounds for the prevention of oxidative stress
\n– Metabolomics characterization of bladder cancer
\n– Search for enzymes working at low temperature in Antarctic\u2019s organisms<\/p>\n
Collaborations:<\/p>\n
Departments at University of Rome \u201cTor Vergata\u201d<\/p>\n
– Chemical Science and Technology
\n– Experimental Medicine and Biochemical Science
\n– Internal Medicine
\n– Clinic Biochemistry
\n– Policlinico Tor Vergata<\/p>\n
Italian Institutions and Companies<\/p>\n
– Centro Nazionale Composti Chimici e Screening, (CNCCS), consorzio pubblico privato CNR-ISS-IRBM
\n– IRBM Science Park, Pomezia
\n– Universit\u00e0 di Roma \u201cLa Sapienza\u201d
\n– Policlinico Umberto I, Roma
\n– Istituto di Biologia Cellulare, CNR
\n– Istituto dei Sistemi Complessi, CNR
\n– Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 Vita-Salute San Raffaele, Milano
\n– Ministero dell\u2019Istruzione, dell’Universit\u00e0 e della Ricerca, Programma Nazionale di Ricerche in Antartide
\n– Bridgestone
\n– Istituto Superiore di Sanit\u00e0
\n– Consorzio C4T<\/p>\n
International Institutions:<\/p>\n
– Universit\u00e0 di Buenos Aires, Argentina
\n– Istituto Fundaci\u00f3n Leloir, Buenos Aires, Argentina
\n– Instituto Ant\u00e1rtico Argentino
\n– Centro di Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda (CIGB), l\u2019Avana, Cuba<\/p>\n
Research Contracts (last five years):<\/p>\n
Research Contracts with CNCCS Consortium (Collezione Nazionale di Composti Chimici e Centro Screening):<\/p>\n
– “NMR Screening to select and improve potential therapeutic compounds for the treatment of Freidreich\u2019s Ataxia”. 01-01-2013\/31-12-2013
\n– “Metabolomica tramite NMR applicata a Malattie Parassitarie”. 01-01-2014\/31-12-2014
\n– “NMR Screening to select and improve potential therapeutic compounds for the treatment of Freidreich\u2019s Ataxia”. 01-01-2014\/31-12-2014
\n– “Screening via NMR di proteine contenenti poli-Q per la scoperta di agenti terapeutici per le malattie neurodegenerative”. 01-01-2014\/31-12-2014
\n– “Malattie Rare neglette e della povert\u00e0”. 01-01-2015\/31-12-2015
\n– “Malattie neglette e della povert\u00e0”. 01-01-2016\/31-12-2016
\n– “Malattie Rare”. 01-01-2016\/31-12-2016
\n– “Friedreich atassia, Metabolomica rischio Cardiovascolare e Piattaforma per la metabolomica quantitativa di matrice biologiche”. 01-01-2017\/31-12-2017
\n– “Nuovi Progetti di Lead Identification tramite HTS”. 01-01-2017\/31-12-2017
\n– “Sviluppo di nuovi agenti anti-Schistosomiasi”. 01-01-2017\/31-12-2017<\/p>\n
National and International Research Grants (last five years)<\/p>\n
\u201cSearch, characterization and evaluation of the biotechnological potential of
\nenzymes active at low temperature from Antarctic organisms\u201d PID-2011-006. Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica, Argentina 01-01-2011\/31-12-2012
\n– \u201cUsing Nuclear Magnetic Resonance to explore key mechanisms of hepatitis C virus proteins\u201d PICT-2009-0099. Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica, Argentina 01-01-2011\/31-12-2012
\n– \u201cRicerca di enzimi che lavorano a temperature estreme di microorganismi antartici\u201d, Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca, Programma Nazionale di Ricerche in Antartide, Italy. 19-06-2014\/18-06-2016<\/p>\n","protected":false},"excerpt":{"rendered":"
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